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KMID : 0356920090570020221
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Korean Journal of Anesthesiology
2009 Volume.57 No. 2 p.221 ~ p.224
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Acute liver injury after sevoflurane anesthesia - A case report -
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Park Jong-Taek
Lee Yeong-Bok
Lim Hyun-Kyo
Ryu Hoon
Kim Jong-Soo
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Abstract
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Halothane, isoflurane and desflurane are metabolized to hepatotoxic trifluoroacetyl proteins. But sevoflurane is metabolized to hexafluoroisopropanol. Hexafluoroisopropanol has a low binding affinity for liver protein and is therefore rapidly converted to glucuronidate that are excreted in the urine. Thus sevoflurane has been considered to have a very low potential for hepatotoxicity. We report a case of a 67 years old woman who developed acute hepatic dysfunction after sevoflurane anesthesia.
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KEYWORD
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Hepatotoxicity, Sevoflurane
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